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Uncover the molecular mechanism of CXCR2

Chemokines and their receptors mediate cell migration, which influences multiple fundamental biological processes and disease conditions, such as inflammation and cancer. Our team has successfully illuminated the molecular mechanism of CXCR2 binding to its endogenous ligand IL8 peptide. CXCR2 has been considered to play an essential role in different oncology pathway and our findings provided new insights into cancer drug discovery. This work has been published in Nature recently. The full text can be found here.

Tags: drug discovery GPCR CXCR2 activation